Advances in Pathogenesis of Idiopathic Membranous Nephropathy
نویسندگان
چکیده
منابع مشابه
Pathogenesis of membranous nephropathy: update.
Membranous nephropathy (MN) is the most common cause of adult nephrotic syndrome and it accounts for about 25% of renal biopsies done for this syndrome. Most of the cases are primary or idiopathic in nature while only about one third of the cases are secondary to some known disease.This review describes the recent advances regarding pathogenesis. Membranous nephropathy is an organ specific auto...
متن کاملTreatment of idiopathic membranous nephropathy.
Exciting progress recently has been made in our understanding of idiopathic membranous nephropathy, as well as treatment of this disease. Here, we review important advances regarding the pathogenesis of membranous nephropathy. We will also review the current approach to treatment and its limitations and will highlight new therapies that are currently being explored for this disease including Ri...
متن کاملChapter 7: Idiopathic membranous nephropathy
BACKGROUND The diagnosis of MN is made on kidney biopsy. Diagnostic features include capillary wall thickening, normal cellularity, IgG and C3 along capillary walls on immunofluorescence, and subepithelial deposits on electron microscopy. MN is often seen in association with an underlying disorder (secondary MN). Secondary MN is more common in children (75%) than adults (25%) (Table 12). The di...
متن کاملTreatment with rituximab in idiopathic membranous nephropathy
BACKGROUND Rituximab represents a valid therapeutic option to induce remission in patients with primary glomerulonephritis. Despite several studies proving its efficacy in improving outcomes in patients with membranous nephropathy (MN), its role in therapeutic protocols is not yet defined. METHODS We studied 38 patients with idiopathic MN treated with rituximab (in 13 patients as first-line t...
متن کاملAntibodies and the Pathogenesis of Membranous Nephropathy
Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy (MN), inspired by studies of Heymann nephritis, a faithful experimental model. These studies led to the identification of neutral endopeptidase, the type-M phospholipase A 2 receptor (PLA 2 R), and cationic bovine serum albumin as target antigens of c...
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ژورنال
عنوان ژورنال: Kidney Diseases
سال: 2020
ISSN: 2296-9381,2296-9357
DOI: 10.1159/000507704